Is Cytochrome Oxidase a Constituent of Nuclear Membranes?
نویسندگان
چکیده
منابع مشابه
Cytochrome cbb3 of Thioalkalivibrio is a Na+-pumping cytochrome oxidase.
Cytochrome c oxidases (Coxs) are the basic energy transducers in the respiratory chain of the majority of aerobic organisms. Coxs studied to date are redox-driven proton-pumping enzymes belonging to one of three subfamilies: A-, B-, and C-type oxidases. The C-type oxidases (cbb3 cytochromes), which are widespread among pathogenic bacteria, are the least understood. In particular, the proton-pum...
متن کاملCopper electron-nuclear double resonance of cytochrome c oxidase.
Electron-nuclear double resonance of copper was observed while monitoring the "intrinsic copper" electron paramagnetic resonance signal of cytochrome c oxidase (ferrocytochrome c:oxygen oxidoreductase, EC 1.9.3.1) near g = 2. This unambiguously establishes the presence of the metal (Cua) in the redox center responsible for this signal. The hyperfine couplings to copper are largely istropic and ...
متن کاملEvolution of the nuclear-encoded cytochrome oxidase subunits in vertebrates.
Vertebrate mitochondrial cytochrome c oxidase (COX) possesses 10 nuclear-encoded subunits. Six subunits have paralogs in mammals, but the origins and distribution of isoforms among vertebrates have not been analyzed. We used Bayesian phylogenetic analysis to interpret the origins of each subunit, inferring the roles of gene and genome duplications. The paralogous ancestries of five genes were i...
متن کاملCytochrome oxidase: a perspective
Cytochrome oxidase from beef heart mitochondria is a 2O4 kDa large protein consisting of 13 subunits of which the numbers 1-111 are encoded by the mitochoridrial DNA, while the remaining subunits (IV-VIII) are encoded by the nuclear genome. The protein contains 2 iron heme groups (cytochrome a and cytochrome a3), 2 Cu centres (CUA and CUB) and 1 Zn atom. The heme groups and the CuB centre are l...
متن کاملCytochrome C Oxidase Activity in Interpopulation Hybrids of a Marine Copepod: a Test for Nuclear-nuclear or Nuclear-cytoplasmic Coadaptation.
The respiratory enzyme cytochrome c oxidase (COX) is composed of subunits encoded by both nuclear and mitochondrial genes; thus, COX activity reflects, to some extent, the coordinated function of the two genomes. Because extensive mtDNA differentiation exists between populations of the copepod Tigriopus californicus, we hypothesized that laboratory hybridizations that disrupt natural combinatio...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1974
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)42098-x